dementia secrets - PanAsiaBiz News

Dementia is a devastating condition that affects millions of people worldwide. It causes cognitive impairment, memory loss, and behavioral changes that interfere with daily life. But what are the genetic factors that increase the risk of developing dementia? In a recent study, NIH scientists discovered two key risk factors that are linked to dementia: a rare variant of the APOE gene and a common variant of the TREM2 gene. These genes are involved in the immune system and the clearance of amyloid-beta, a toxic protein that accumulates in the brains of people with Alzheimer's disease, the most common form of dementia. The researchers analyzed the genomes of more than 6,000 people with dementia and 5,000 healthy controls. They found that people who carried both the APOE and TREM2 variants had a 12-fold higher risk of developing dementia than those who did not. The APOE variant alone increased the risk by 3.8 times, while the TREM2 variant alone increased it by 2.6 times. The study also revealed how these genes interact with each other and with amyloid-beta. The APOE variant reduces the ability of immune cells called microglia to clear amyloid-beta from the brain. The TREM2 variant enhances the inflammatory response of microglia to amyloid-beta, which can damage brain cells and worsen cognitive decline. The findings suggest that targeting these genes or their pathways could be a promising strategy for preventing or treating dementia. The researchers hope that their study will inspire more research on the genetic and environmental factors that contribute to this complex and challenging disease.

Unraveling Dementia’s Secrets: NIH Finds Genes That Increase Risk

May 15, 2023 S Ranjita 0

Dementia is a devastating condition that affects millions of people worldwide. It causes cognitive impairment, memory loss, and behavioral changes that interfere with daily life. […]

Photos: Mrunal Thakur Stuns in Sporty Chic Look at Mumbai Hotspot

Mrunal Thakur was spotted exiting a popular Mumbai restaurant, turning heads with her effortlessly stylish and sporty look. Her voluminous hair was left open, adding to the relaxed yet stylish vibe.

Crypto Industry Eyes Big Wins in US Congressional Races

The cryptocurrency industry, including major players like Coinbase and Ripple, has invested over $119 million in supporting pro-crypto candidates in the US congressional elections

Bitcoin Price Could Cross $100,000 If Trump Wins US Presidential Election

Bitcoin could surpass $100,000 if Donald Trump wins US Presidential Election 2024. Market betting sites are overwhelmed by rumors of a Trump win over Kamala Harris.

Triptii Dimri’s Blush Pink Elegance Lights Up Diwali Celebrations

Bollywood star Triptii Dimri has raised the fashion stakes yet again, dazzling in a breathtaking traditional outfit for Diwali. Triptii chose a blush pink saree designed by renowned designer Arpita.

‘Panchayat 3’ OTT Release Date; Jitendra Kumar hints at character evolution

The makers of the show have not yet announced the official release date of 'Panchayat 3', but the lead actor Jitendra Kumar has hinted at some interesting developments in his character's arc.

Ananya Panday Shines in All-Black Ensemble at Lakme Event

Ananya came to Lakme evemt as the brand ambassador for Lakmé Glycolic Illuminate Collection. Her dressing was very great.

‘Mirzapur 3’ OTT Release Date Confirmed, Pankaj Tripathi is Back!

'Mirzapur 3' OTT release date confirmed. We know that Mirzapur 1 and 2 became big hits. Fans and movie lovers are waiting for Mirzapur 3.

India Dominate in 2nd Test against England with Jaiswal and Ashwin’s Brilliance

India vs England 2nd Test highlights. India won the toss and chose to bat. In reply to India's score of 396, England score was 123/2 in 24.5 overs on day two

Kriti Sanon’s Stunning Outfits for ‘Teri Baaton Mein Aisa Uljha Jiya’ Promotional Events

was spotted in a chic outfit for the promotions of her upcoming song 'Teri Baaton Mein Aisa Uljha Jiya'. The song is a romantic track featuring Kriti and Kartik Aaryan

Janhvi Kapoor Faces Backlash Over Awards Show Performance

Janhvi Kapoor faces trolls over award show performance. Her telugu debut movie "Devara" release is also postponed to the second half of 2024 because of pending of VFX work.

View all stories