Study Serves As A Valuable Resource For Lab-based Fetal Tissue Production

The molecular cues that determine the formation of the body structure in the monkey embryo have been found by experts. This will direct research ,into human birth abnormalities including pregnancy loss.

The study also offers a vital benchmark for lab-grown fetal tissue, which is in low supply but required for medication testing and research into stem cell-based remedies to restore body cells in disorders like Parkinson’s.

From a cluster of cells, embryos grow into highly organized structures. The signs driving this metamorphosis, although, have remained concealed from view inside of the uterus until now.

Scientists have built molecular mappings of the 2nd week of pregnancy that have not been seen before by analyzing genetic expression in 3 dimensions. Their findings were published in the magazine Nature today.

The most obscure, yet crucial, phase of development of the embryo is the 2nd week of pregnancy. One of the leading reasons for pregnancy complications and birth abnormalities is the lack of growth during this period.

Boroviak previously demonstrated that the 1st week of growth in marmoset monkeys is strikingly comparable to the 1st week. However, he was unable to investigate week 2 of growth, after the embryo had been implanted into the womb, using existing technologies.

The researchers were able to follow down the early signals triggering the development of the body axes – when the fetus’s symmetrical shape begins to shift – using a new laser-assisted method. One end commits to growing into the brain, while the other end develops into the ‘tail.’

Asymmetric signals are generated by the embryo and temporary systems that sustain the embryo during growth, such as the yolk sac, amnion, and placental precursors.

According to News Medical, Boroviak and his colleagues studied implanted fetuses of the marmoset, a tiny New World monkey, since they are humanlike embryos at this phase of development.

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